D1 | Abstract 08

Annual NUTRIM Symposium 18 November 2020


Effects of an 8-week aerobic exercise program on plasma markers for cholesterol absorption and synthesis in older overweight men

Mashnafi S1,2, Plat J1, Mensink RP1, Joris PJ1, Kleinloog JPD1, Baumgartner S1*

1 Department of Nutrition and Movement Sciences, NUTRIM school of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands
2 Department of Medical Basic Sciences, Faculty of Applied Medical Sciences, AlBaha University, Saudi Arabia

Background and aim:
Increased physical activity is inversely related to the risk to develop cardiovascular disease (CVD). We have recently reported an increased cholesterol absorption and a decreased synthesis in CVD patients as compared with control participants. Therefore, we hypothesized that exercise will reduce cholesterol absorption and increase endogenous cholesterol synthesis in older overweight men.

A randomised, controlled, crossover trial was performed. Seventeen apparently healthy older overweight men were randomised to start with an aerobic exercise or no-exercise control period for 8 weeks, separated by 12 weeks washout. Fasting serum total cholesterol (TC) and non-cholesterol sterol concentrations were measured at baseline, and after 4 and 8 weeks.

The aerobic exercise program did not affect plasma TC concentrations. In addition, exercise did not affect TC-standardized serum concentrations of sitosterol and cholestanol that are markers for cholesterol absorption. However, a trend for reduced TC-standardized campesterol concentrations, which is another validated marker for cholesterol absorption, was observed as compared with control. Lathosterol concentrations, reflecting cholesterol synthesis, did not differ between both periods.

Aerobic exercise training for 8 weeks did not lower serum TC concentrations, but tended to decrease the cholesterol absorption marker campesterol without changing the cholesterol synthesis marker lathosterol in older overweight men.

NUTRIM | School of Nutrition and Translational Research in Metabolism
NUTRIM aims to contribute to health maintenance and personalised medicine by unraveling lifestyle and disease-induced derangements in metabolism and by developing targeted nutritional, exercise and drug interventions. This is facilitated by a state of the art research infrastructure and close interaction between scientists, clinicians, master and PhD students.