Abstracts Staff

74. In vivo, Ex vivo and In vitro analysis of intestinal barrier function

Montserrat Elizalde1

1 Division Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands 

Within the laboratory of the division Gastroenterology-Hepatology, we focus on studying disease, host and lifestyle factors that can impact barrier function and try to unravel the underlying mechanisms. For this purpose, functional analyses in vivo (sugar-tests ), in vitro (cell culture and host organoid models) and ex vivo (Ussing chambers) are performed and combined with other analyses (gene expression, protein levels and localization).

NUTRIM | School of Nutrition and Translational Research in Metabolism
NUTRIM aims to contribute to health maintenance and personalised medicine by unraveling lifestyle and disease-induced derangements in metabolism and by developing targeted nutritional, exercise and drug interventions. This is facilitated by a state of the art research infrastructure and close interaction between scientists, clinicians, master and PhD students.