Students and other high-demanding knowledge workers hardly ever consider improved physical fitness as a strategy to enhance study and work efficiency and quality. In contrast to skeletal muscle which can use different substrates, brain energy metabolism solely relies on glucose. Thus, optimizing glucose metabolism could facilitate cognitive functioning, problem-solving, and academic performance for students. In controlled experimental settings, we will evaluate the impact of timing of nutrition and physical activity on brain glucose supply and cognitive functioning separately. Subsequently, we will develop a combined nutrition and physical activity intervention. In these studies, we will evaluate as primary outcomes academic performance and cognitive functioning. The secondary outcomes are cerebral blood flow (CBF), glucose concentrations, and blood parameters. Blood parameters include high density lipoprotein (HDL), low density lipoprotein (LDL), free fatty acid (FFA), and brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), insulin-like growth factor-I (IGF-I), epinephrine, norepinephrine, and dopamine.