Abstracts Division 3
70. 1-minute sit-to-stand and 6-minute walking test to assess responders of pulmonary rehabilitation: are they similar?
Sara Souto-Miranda1,2,3, Maria A. Mendes4, João Cravo4, Lília Andrade4, Martijn A. Spruit3,5, Alda Marques1,2
1 Lab3R - Respiratory Research and Rehabilitation Laboratory,
School of Health Sciences (ESSUA), University of Aveiro, Aveiro, Portugal
2 Institute of Biomedicine (iBiMED), University of Aveiro,
Portugal
3 Department of Respiratory Medicine, Maastricht University
Medical Centre, NUTRIM School of Nutrition and Translational Research in
Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht
University, The Netherlands
4 Department of Pulmonology, Centro Hospitalar do Baixo
Vouga, E.P.E., Aveiro, Portugal
5 Department of Research and Development, CIRO, Horn, The
Netherlands
Background
The distance in the 6-min walking test (6MWT) has been a largely studied outcome of pulmonary rehabilitation (PR) in people with chronic obstructive pulmonary disease (COPD). Much less is however known about the response to PR in other meaningful activities of daily living. This study aimed to explore responders and non-responders to PR in 1-minute sit-to-stand test (1-min STS) and 6MWT, predictors of response, and to compare both measures in classifying responders and non-responders to PR.
Methods
An observational study was conducted with people with COPD. Functional status was assessed before and after a 12-week community-based PR programme. Paired samples t-tests were used to assess the effects of PR. Responders and non-responders were classified using minimal clinically important differences. Predictors were explored with correlations and binary logistic regressions. Agreement between both measures in classifying responders was assessed with Chi-square or Fisher exact tests, Cohen’s kappa and McNemar tests.
Results
Ninety-four people with COPD were included (80.9% male, FEV1 49.8±18.4% predicted). Both 1-min STS and 6MWT improved after PR (p<0.001), and changes in both measures were correlated (rs=0.398, p<0.001). There were 51.1% and 60.6% of responders in the 1-min STS and 6MWT respectively (p=0.013), with a small agreement between the two measures (kappa=0.252, pkappa=0.013, pMcNemar=0.175). Responders had higher baseline BMI, which was a predictor of response with increases in 1 kg/m2 corresponding to increased odds of being a good responder (1-min STS: p=0.024, OR=1.125 95%CI [1.016-1.247], pseudo-r2=0.057; 6MWT: p=0.039, OR=1.118 95%CI [1.006-1.243], pseudo-r2=0.048).
Conclusion
A significant amount of non-responders to PR in functional status exists, and higher baseline BMI seems to be a predictor of good response. 1-min STS and 6MWT should not be used interchangeably. Future studies should explore the added benefit of personalising PR for this outcome and investigate other factors influencing the response.
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