Abstracts Division 2
34. Dietary advanced glycation endproducts and intestinal inflammation in IBD and IBS patients
Marlijne C.G. de Graaf1,2, Corinne E.G.M. Spooren1,2, Evelien M.B. Hendrix1,2,
Martine A.M. Hesselink1,2, Jean L.J.M. Scheijen3,4,
Casper G. Schalkwijk3,4, Zlatan Mujagic1,2, Marieke J.
Pierik1,2, Daniel Keszthelyi1,2, Daisy M.A.E. Jonkers1,2
1 Division of Gastroenterology-Hepatology, Department of Internal Medicine, Maastricht University Medical Center,
Maastricht, the Netherlands
2 NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands
3 Department of Internal Medicine, Maastricht University Medical Center, the Netherlands
4 CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands
Background
The Western diet is associated with both inflammatory bowel disease (IBD) and irritable bowel
syndrome (IBS) and patients often perceive specific food items as trigger for
flares or symptoms. In general, a Western diet is rich in processed food and
comprises high levels of advanced glycation endproducts (AGEs). This complex
group of compounds can have e.g. oxidative and inflammatory properties. We
aimed to investigate the intake of dietary AGEs in IBD and IBS patients, and
the association with intestinal inflammation.
Methods
A cross-sectional study was performed in 238 IBD patients, 261 IBS patients and 195 healthy
controls (HC). Habitual dietary intake over the previous month was assessed
using validated food frequency questionnaires. These data were combined with
databases on the amount of dietary AGEs in food products measured by
ultraperformance liquid chromatography-tandem mass spectrometry, to calculate
the daily intake of three important dietary AGEs: Ne-carboxymethyl-lysine (CML), Ne-carboxyethyl-lysine (CEL) and methylglyoxal-derived hydroimidazolone-1 (MG-H1). The association between dietary AGEs and faecal calprotectin, as marker of intestinal inflammation, was analysed using
multivariable linear regression.
Results
The absolute dietary AGEs intake did not differ between IBD and HC, but was lower in IBS compared to HC (CML 3.53±1.22 vs. 3.05±1.12 vs. 3.43±1.22mg/day;
CEL 2.92±1.03 vs. 2.57±0.90 vs. 2.82±1.05mg/day;
MG-H1 22.82±7.99 vs. 20.10±7.34 vs. 23.24±7.91mg/day;
IBS vs. HC p<0.001). After adjustment for total energy intake, the dietary
AGEs intake was no longer significantly different between IBS and HC. Faecal
calprotectin levels were not significantly associated with absolute intake or
energy-adjusted intake of total or individual dietary AGEs in either of the
subgroups.
Conclusion
The intake of dietary AGEs was not significantly associated with intestinal inflammation in
IBD and IBS patients. Further insight is needed in other AGEs and in vivo
concentrations, especially given the microbiome perturbations in both patient
groups.
NUTRIM | School of Nutrition and Translational Research in Metabolism
NUTRIM aims to contribute to health maintenance and personalised medicine by unraveling lifestyle and disease-induced derangements in metabolism and by developing targeted nutritional, exercise and drug interventions. This is facilitated by a state of the art research infrastructure and close interaction between scientists, clinicians, master and PhD students.
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