D1 | Abstract 04

Annual NUTRIM Symposium 18 November 2020


The Effect of a Low Calorie Low Inflammatory Diet on Inflammation, Telomere Length and Mitochondrial DNA among Obese Adults.

Harry Freitag Luglio Muhammad1; Marleen van Baak2; Edwin Mariman2; Sukma Oktavianthi3; Safarina G. Malik3

1Department of Nutrition and Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada
2NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University
3Eijkman Institute for Molecular Biolog
The objective of this study was to investigate the effect of a low calorie low inflammatory diet (LCID) on inflammation markers, body weight, metabolic syndrome parameters, mitochondrial DNA copy number (mtDNA-CN) and relative telomere length (RTL) in obese adults.

This is a randomized controlled trial among Indonesian adults with obesity. Participants (n=61) were divided into 2 groups: low-calorie diet (LCD) (n=30) and low calorie low inflammatory diet (LCID) (n=31). The LCID was an adaptation of the Mediterranean diet principle to a low calorie diet regime. The length of the weight loss program was 8 weeks, and participants were followed for 8 weeks of the weight maintenance period.

Subjects in the LCID group had a lower hs-CRP (p=0.03) compared to those in the LCD group, but no difference was seen in plasma levels of TNF- α (p=0.32) and IL-6 (p=0.63). Subjects in both groups had a significant reduction in body weight, body fat, lipid profile and blood pressure (all p<0.05) with no differences between groups (all p>0.05). The mtDNA-CN was unchanged (p=0.96) after weight loss while RTL was shown to be increased (p=0.002). Changes in RTL were higher in LCID than those in the LCD group (p=0.036), while mtDNA-CN showed no difference. Weight changes after weight loss and maintenance period were not associated with inflammation markers, mtDNA-CN or RTL (all p>0.05).

This study showed that the LCID had a beneficial effect on hs-CRP during a weight loss intervention compared to the LCD, but not on TNF- α and IL-6. The weight loss program was associated with the elongation of telomere length and those in LCID responded with significantly longer telomeres as compared to LCD despite a similar degree of weight loss.

NUTRIM | School of Nutrition and Translational Research in Metabolism
NUTRIM aims to contribute to health maintenance and personalised medicine by unraveling lifestyle and disease-induced derangements in metabolism and by developing targeted nutritional, exercise and drug interventions. This is facilitated by a state of the art research infrastructure and close interaction between scientists, clinicians, master and PhD students.